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Adipex Pill.This drug primarily used as an appetite suppressant. Chemically, Adipex Pill is an amphetamine (and a phenethylamine). Adipex Pill is typically prescribed for individuals who are at increased medical risk because of their weight, as opposed to cosmetic weight loss. Adipex Pill is sold either as an immediate-release formulation (Adipex) or as a slow-release resin (Ionamin, Duromine in Australia and New Zealand).
Patients diagnosed with panic disorder were included among participants in the study. Fifty patients were given either the Adipex Pill or a Adipex Pill during an 8-week double-blind controlled study. Results proved that both somatic and psychic anxiety was decreased significantly in those who took the Adipex Pill, compared to the Adipex Pill.

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In 1959 Adipex Pill first received approval from the FDA as an appetite suppressing drug. Adipex Pill hydrochloride then became available in the early 1970s. It was previously sold as Fastin from King Pharmaceuticals for SmithKline Beecham, however in 1998 it was removed from the market. Medeva Pharmaceuticals sells the name brand of Adipex Pill called Ionamin® and Gate Pharmaceuticals sells it as Adipex-P®. Adipex Pill is also currently sold as a generic. Since the Adipex Pill was approved in 1959 there have been almost no clinical studies performed. The most recent study was in 1990 which combined Adipex Pill with fenfluramine or dexfenfluramine and became known as Fen-Phen.



Adipex Pill is still available by itself in most countries, including the U.S. However, because it is similar to amphetamines, individuals may develop an addiction to Adipex Pill. Hence, it is classified as a controlled substance in many countries. Internationally, Adipex Pill is a schedule IV drug under the Convention on Psychotropic Substances.[1] In the United States, it is classified as a Schedule IV controlled substance under the Controlled Substances Act.

Adipex Pill, works with neurotransmitters in the brain. As a result, Adipex Pill causes a loss in appetite because the brain does not receive the hunger message.


Adipex Pill is recommended by the Food and Drug Administration (FDA) that Adipex Pill should be used short-term (up to 12 weeks), while following nonpharmacological approaches to weight loss such as healthy dieting and exercise. However, recommendations limiting Adipex Pill use for short-term treatment may be controversial. One reason given behind limiting its use to 12 weeks is drug tolerance, whereby Adipex Pill loses its appetite-suppressing effects after the body adjusts to the drug. On the contrary, it has been shown that Adipex Pill did not lose effectiveness in a 36-week trial.[2] Due to the risk of insomnia, it is generally recommended that the drug be taken either before breakfast or 1-2 hours after.

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Generally, Adipex Pill appears to be relatively well tolerated.Adipex Pill can produce side effects consistent with its catecholamine-releasing properties, e.g., tachycardia, increased heart rate, increased alertness, but the incidence and magnitude of these appear to be less than with the amphetamines. Because phentermine acts through sympathomimetic pathways, the drug may increase blood pressure and heart rate. Adipex Pill may also cause palpitations, restlessness, and insomnia. Additionally, individuals taking this drug on a long-term basis may develop euphoria and a psychological addiction to it.

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Adipex Pill is a centrally-acting stimulant and is a constitutional isomer (not to be confused with stereoisomer) of methamphetamine. It stimulates neuron bundles to release a particular group of neurotransmitters known as catecholamines; these include dopamine, epinephrine (also known as adrenalin), and norepinephrine (noradrenaline). The anorectic activity seen with these compounds would thus seem likely due to this effect on the central nervous system, which is consistent with current knowledge about central nervous system systems and feeding behavior. This is the same mechanism of action as other stimulant appetite suppressants such as diethylpropion and phendimetrazine. The neurotransmitters signal a fight-or-flight response in the body which, in turn, puts a halt to the hunger signal.

Although Adipex Pill was never approved by the FDA the agency did approve of the drug. A study was published in 1992 that Adipex Pill was more effective than diet and exercise with few side effects. However, in 1997 after 24 cases of heart valve disease in Adipex Pill users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. Studies later proved that nearly 30% of people taking fenfluramine or dexfenfluramine had abnormal valve findings. The FDA did not ask manufacturers to remove Adipex Pill from the market.